Patent Applications

1.   Wang, P. G.; Chen, X.; Liu, Z. Y.; Zhang, W. Glycoconjugate synthesis using a pathway-engineered organism, UA2002132320.

2.   Wang, P. G.; Chen, X. Glycoconjugate and sugar nucleotide synthesis using solid supports, UA2002150968, WO0255723.

3.   Chen, X.; Saribas, S.; Barthelson, R.; Mobasseri, A.; Kelly, J.; Otvos-Papp, E.; Pristatsky, P.; Wang, J.; Stevenson, T. T. Manufacture of heparin for anticoagulant using transgenic microorganisms and heparin precursors. PCT Int. Appl. (2004), 118 pp. WO2004017910 A2 20040304.

4.   DeFrees, S.; Zopf, D.; Bayer, R.; Bowe, C.; Hakes, D.; Chen, X.  Glycan remodeling and glycoconjugation of peptides and proteins. PCT Int. Appl.  (2003), 900 pp. WO 2003031464 A2 20030417.

5.   Defrees, S.; Zopf, D.; Bayer, R.; Bowe, C.; Hakes, D.; Chen, X. Cell-free, in vitro method for regioselective, enzymic glycoPEGylation of peptides. U.S. Pat. Appl. Publ. (2004), 752 pp., Cont.-in-part of Appl. No. PCT/US02/32263. US 2004132640 A1 20040708.

6.   Defrees, S.; Zopf, D.; Bayer, R.; Bowe, C.; Hakes, D.; Chen, X. Methods for glycan remodeling and glycoPEGylation of therapeutic proteins. U.S. Pat. Appl. Publ. (2004), 690 pp., Cont.-in-part of U.S. Ser. No. 360,779. US 2004142856 A1 20040722.

7.   Defrees, S.; Zopf, D.; Bayer, R.; Bowe, C.; Hakes, D.; Chen, X. Methods for glycan remodeling and glycoPEGylation of therapeutic proteins. U.S. Pat. Appl. Publ. (2004), 754 pp., Cont.-in-part of U.S. Ser. No. 360,779. US 2004126838 A1 20040701.

8.   DeFrees, S.; Zopf, D.; Bayer, R.; Bowe, C.; Hakes, D.; Chen, X. Glycan remodeling and glycoconjugation of b-interferon. U.S. Pat. Appl. Publ. (2004), 761 pp., Cont.-in-part of U.S. Ser. No. 360,779.  US 2004115168 A1 20040617.

9.   DeFrees, S.; Zopf, D.; Bayer, R.; Bowe, C.; Hakes, D.; Chen, X. Glycan remodeling and glycoconjugation of interferon a and use thereof for treatment of hepatitis C. U.S. Pat. Appl. Publ.  (2004), 761 pp., Cont.-in-part of U.S. Ser. No. 360,779. US 2004082026 A1 20040429.

10. DeFrees, S.; Zopf, D.; Bayer, R.; Bowe, C.; Hakes, D.; Chen, X. Erythropoietin glycosylation and the modification of protein structure and activity for therapeutic use. PCT Int. Appl. (2004), 1018 pp. WO 2004033651 A2 20040422.

11. DeFrees, S.; Zopf, D.; Bayer, R.; Bowe, C.; Hakes, D.; Chen, X. Glycan remodeling and glycoconjugation of granulocyte colony stimulating factor. U.S. Pat. Appl. Publ.  (2004), 754 pp., Cont.-in-part of U.S. Ser. No. 360,779. US 2004077836 A1 20040422.

12. DeFree, S.; Zopf, D.; Bayer, R.; Hakes, D.; Chen, X. Remodeling of protein-linked oligosaccharide moieties and the resulting glycoproteins and glycopeptides. U.S. Pat. Appl. Publ.  (2004), 749 pp., Cont.-in-part of U.S. Ser. No. 360,779. US 2004063911 A1 20040401.

13. DeFrees, S.; Zopf, D.; Bayer, R.; Bowe, C.; Hakes, D.; Chen, X. Methods for cell-free remodeling and glycoconjugation of glycopeptides, remodeling of a-galactosidase A peptides, and their therapeutic use for Fabry disease. U.S. Pat. Appl. Publ.  (2004), 761 pp., Cont.-in-part of Appl. No. PCT/US02/32263. US 20040043446 A1 20040304.

14. De Frees, S.; Zopf, D.; Bayer, R.; Bowe, C.; Hakes, D.; Chen, X. Cell-free oligosaccharide remodeling and glycoPEGylation methods and the proteins/peptides produced. PCT Int. Appl. (2004), 1024 pp. WO  2004099231 A2 20041118.

15. Defrees, S.; Zopf, D.; Bayer, R.; Bowe, C.; Hakes, D.; Chen, X. Cell-free in vitro glycoconjugation of interleukin 2 as therapeutic agent against cancer and AIDS in mammal and human. U.S. Pat. Appl. Publ.  (2005), 750 pp., Cont.-in-part of U.S. Ser. No. 360,779. US 2005031584 A1 20050210.

16. Defrees, S.; Zopf, D.; Bayer, R.; Bowe, C.; Hakes, D.; Chen, X.  Cell-free in vitro glycan remodeling and enzymic glycoconjugation of Factor IX for treating hemophilia B. U.S. Pat. Appl. Publ. (2005), 761 pp., Cont.-in-part of U. S. Ser. No. 360,779. US 2005100982 A1 20050512.

17. Johnson, K. F.; Chen, X.; Taudte, S.; Saribas, S. Truncated polypeptide N-acetylgalactosaminyltransfersease II polypeptides and nucleic acids. PCT Int. Appl. (2005). 123 pp. WO 2005121331 A2 20051222.

18. Defrees, S.; Zopf, D.; Bayer, R.; Bowe, C.; Hakes, D.; Chen, X.  In-vitro remodeling and glycoconjugation of erythropoietin. U.S. Pat. Appl. Publ. (2007), 754 pp., Cont.-in-part of Appl. No. PCT/US02/32263. US 2007042458 A1 20070222.

19. Defrees, S.; Zopf, D.; Bayer, R.; Bowe, C.; Hakes, D.; Chen, X. In-vitro remodeling of therapeutic peptides using modified galactosyl nucleotides. U.S. Pat. Appl. Publ. (2008), 746pp., Cont.-in-part of U.s. Ser. No.360,779. US 2008206808 A1 20080828.

20. Defrees, S.; Zopf, D.; Bayer, R.; Bowe, C.; Hakes, D.; Chen, X. Cell-free in vitro glycan remodeling and glycoPEGylation of Factor VIIa and other polypeptides. U.S. Pat. Appl. Publ. (2010), 750 pp., Cont.-in-part of U.S. Ser. No. 360,779. US 2010015684 A1 20100121.

21. Chen, X.;  Yu, H.; Li, Y.; Chen, Y. Chemoenzymatic synthesis of heparin and heparan sulfate analogs. Provisional Patent Application. Family ID No. 205000US. Filed 7/21/2011.

22. Chen, X.;  Sugiarto, G.; Lau, K. PmST1 mutant for chemoenzymatic synthesis of sialyl Lewis x compound. Provisional Patent Application. Application Number: 61515702. Filed 8/5/2011.

23. Chen, X.; Thon, V.; Lau, K. A novel glycolipid a2-3-sialyltransferase and methods of glycolipid synthesis. Family ID No. 210800US. Filed 2011.

24. Chen, X.; Thon, V.; Yu, H. a2-3-sialyltransferase for the synthesis of sialosides and sialyl glycolipids. Family ID No. 210901US. Filed 2011.

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